Antibiotic may damage liver in some, study shows

You will be automatically forwarded in 3 seconds...

Highlight:
According to an online report of the Annals of Internal Medicine, the antibacterial agent telithromycin may be linked to severe liver toxicity in some cases.

Original source:
http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2006-01-25T213435Z_01_KRA577640_RTRUKOC_0_US-LIVER-FAILURE.xml

Summary:

• Physicians in Charlotte, North Carolina describe three cases of severe liver toxicity that appear to have been caused by the antibacterial agent telithromycin, according to an online report of the Annals of Internal Medicine.
• Although there have been other reports of liver toxicity associated with telithromycin, "the biggest difference here was the outcome, with one patient dying and one requiring liver transplantation, which have not been reported before," co-author Dr. John S. Hanson, from Carolinas Medical Center, told Reuters Health.
• He emphasized that "since being approved by the FDA in late 2004 there have been 2.7 million prescriptions written, so this type of reaction is quite rare."
• Bacteria that are resistant to other antibiotics are often still sensitive to telithromycin, according to the article.
• The three patients were first seen with symptoms of jaundice and markedly abnormal results on liver function tests within a few days of receiving telithromycin.
• One patient improved upon withdrawal of telithromycin.
• Jaundice resolved within two weeks, and the patient's liver enzyme levels normalized by week eight.
• The second patient developed jaundice while on telithromycin.
• Liver enzyme levels were elevated, and abdominal ultrasound tests revealed liver abnormalities.
• One month later, CT scans showed a small liver and an enlarged spleen.
• In the latter two cases, the authors report, tissue examination showed massive liver disease consistent with drug-induced injury.
• "At this point, these cases appear to be an idiosyncratic reaction, and it's difficult to sort out what the mechanisms are because there are probably many factors at play," Hanson said.
• Two of the patients reported moderate alcohol use, he noted, "but when we did pathologic examinations of the livers there was no evidence of alcohol injury."
• Dr. Hanson added: "As with any medication change, physicians should tell patients to alert the physician to any major significant change in any symptoms.
• Certainly if someone all of a sudden develops jaundice, nausea or vomiting," which suggest liver dysfunction.

See more articles and news on antibiotic

Stay informed

• 100% free of charge. Unsubscribe anytime.
• Absolutely no spam. We respect your privacy.
• Choose from topics like natural health, renewable energy, the environment, emerging technology and more.
• Receive a free instant download of our $29 Secret Sources guide that reveals top sources for little-known health and diet solutions.

This page powered by the WebSeed Content Management System (CMS) created by Mike Adams.

PDR for Herbal Medicines, Third Edition

Related article:
Emphasis on performance measures may lead to inappropriate antibiotic use (press release)

Free downloadable books and reports on health, disease prevention and emerging technology at TruthPublishing.com.